Winnipeg Free Press

Winnipeg Free Press (Newspaper) - November 21, 1996, Winnipeg, Manitoba The health Page editor Buzz 69723t keeping the heart ticking researchers work May curb the need for transplants the human heart is surely an altruistic consider that it must beat at least an average of 60 times per minute to pump blood to All of the various organs of the this translates to Over beats per Day or Over 31 billion beats per to beat this Many the heart requires a great Deal of if disease decreases the production of Energy in the it May develop irregular beats called these May affect the delivery of blood not Only to the heart muscle but to other body organs life threatening much is known about How the heart and other body tissues produce ener but much less is known about the regulation of these Energy general ing processes in health and important component the research conducted by Grant Hatch focuses on the Regula Tion of Energy Rich chemicals in the heart called phospholipids phosphor Rou containing lipids or these phospholipids Are widely spread throughout the body and Are an important component of the Wall that surrounds every cell in the human not just in the one especially important Phospholipid in the heart and other tissues is called Cardi Lipin and it was discovered Back in Cardi Lipin is essential for the activation of Energy production by cells in the Energy required to keep the heart beating so Many times every minute after the facts is a column about research at the University of it will run Onee a month on the health this months Gary is head of the department of pharmacology and therapeutics in the University of Manitoba faculty of Ken Miquon Winnipeg free press Grant Hatch work focuses on the regulation of Energy Rich chemicals in the human of every when Hatch came to the faculty of Medicine in Little was known about Cardi Lipin production in the since that who is an assistant professor in the depart ment of pharmacology and thera Peu has been investigating several factors that control Cardi Lipin production by the he and his colleagues have shown that there Are four critical enzymes proteins that regulate the Speed and the nature of chemical reactions in the body that control the manufacture of Cardi Lipin in the the first of these enzymes appears to regulate the Pace at which Cardi r re not youre As you can yellow gets you not Cedas a that just what you be when youre in the yellow its where Consumers go when there ready to its advertising they actually want to read and with a wide Range of display and and the additional colours now you can create effective ads suited to your product or and your this make sure you have it in yellow make the yellow part of your advertising Pla Call us at 941 c advanced Lipin is Hatch was Able to show that this Pace setting enzyme is itself controlled by the Energy level of the he discovered that when the heart suffers from a reduced Supply of As can happen in cases of coronary artery disease there is a decrease in production of a sub stance called cup is required for Cardi Lipin cup is Cardi Lipin production is Low and the heart May not have enough Energy to beat this insight opens up Many possibilities for the design of drugs that will help regu late and increase Energy Levels in the constantly beating in it often happens that a drug shown to be useful in one is also found to have a use in other Hatch has collaborated with Grant Mcclarty of the department of medical microbiology and they have uncovered an Excel Lent example of this they have Dis covered that an Antitumor drug called cyclopes Teny cytosine Lowers the level of cup in heart it lowered not Only Cardi Lipin but also production of most other phospholipids in these heart at the same the production of triglycerides or fats by these cells All of these effects were for the first Hatch and his colleagues discovered a single acts As a Universal switch or trigger that can turn on or turn off Cardi Lipin production in the the design of specific drugs that can control this switch without being toxic to the heart will result in a major clinical Advance in the management of heart it will also have implications for Overall body Energy control and the management of Energy Levels in the heart Are also controlled by thyroid groundbreaking research holds Hope for major clinical Vance ement i h atch has shown that thy roid hormones elevate Cardi Lipin Levels in the he is investigating the com plex interrelationship Between thy roid function and heart function with respect to the Overall control of car Diac diabetes is a major risk Factor for the development of heart diabetic patients have two to five times the incidence of heart disease that non diabetics there is a specific heart disease associated with diabetes that is not related to coronary artery disease blockage commonly observed in card Ift Many researchers feel that Dia Bete induced heart disease is related to defective Energy production in the Hatch is studying the involvement of Cardi Lipin production in the development of heart Dis ease in diabetes and has shown that the production of Cardi Lipin is decreased in experimental conditions that mimic poor diet in poorly controlled diabetes As a result of poor diet or the failure to take insulin on a regular another enzyme that regulates Cardi Lipin synthesis is Ogeth these observations suggest that heart disease seen in diabetes May be in to altered Cardi Lipin production in the even More All of the cardiac enzyme changes seen in diabetes could be reversed with insulin treat Hatch is now searching for a drug that can enhance the actions of insulin on cardiac Energy regulating he is also investigating the role of Cardi Lipin in the control of cell growth and cell this work has very important Conse q u e n c e s especially for the regeneration of cardiac tissue after a heart attack in which there is actual tissue death in the heart that results in permanent to the Only solution to a very severely damaged heart is its replacement via a heart Hatch work May make this danger Tousand expensive operation unnecessary in the Hatch is also a member and the coordinator of the lipid up protein and atherosclerosis research group larg at the University of Manito this is a number of scientists from several medical and research departments interested in studying the mechanisms involved in the development of cardiovascular up proteins Are Small molecules in the blood that transport cholesterol and triglycerides elevated Levels of one of these Bdl or Low density Lipoprotein has been associated with an increased risk of coronary artery this research group is studying the pharmacological manipulation of processes leading to coronary artery blockage in patients with High Levels of plasma cholesterol and Hatch scientific excellence has been rewarded with a prestigious scholarship award from the heart and stroke foundation of his research work is supported by the foundation As Well As by the medical research Council of Canada and the Manitoba health research for further Pfow the hot i stroke future shop Muiir Slatus correction notice in our Ttyler cunning 21 26 the following error occurred the general electric answering machine at should have read not exactly As the future shop sincerely regrets any inconvenience this May have caused our valued correction notice 12 Mai wanted Cudd ibid camera to dates Noi Haye Aro a Kilts not a a facture Jug substituting with e Cor few Motif cd of this the error listen ate appeared in our we sincerely regret Sny or confusion to our Eaton ;