Winnipeg Free Press

Winnipeg Free Press (Newspaper) - November 26, 1996, Winnipeg, Manitoba Winnipeg Attr Mettiet Gene tale no flight of fancy Tumours remain harmless until transformed into malignant cells by Alexandra Paul do reporter the classic horror Story of Jekyll and Hyde tells the tale of the respectable Jekyll who drinks a secret potion that separates the Good and evil aspects of his the result is the hideous murderer Back in when Robert Louis Stevenson wrote the he believed it was a flight of now science has discovered a Bio logical truth hidden in the a team of Winnipeg led by University of Manitoba molecular biologist Jim has discovered a Gene that behaves like Jekyll and the Gene is contained in the Dan of mammal on including its called rib Nucleotide Reductase benign face the r2 Gene showed its benign Jekyll face to scientists years ago when it was identified As critical to the process of cell As the r2 Gene provides the building blocks for making new Dan and helps cells Divide and mul the Gene ensures the genetic code of is passed Down through the the same Gene pro Vides the building blocks for Dan to repair itself when it is Wright said that As Long As r2 is working life keeps it applies to Wright no one knew the same Gene had a latent sinister role that can also destroy life crowding it out in an overgrown Jungle of malignant can boy was familiar with police say opens Gene therapy door Wright examines xray expression of r2 Gene As Cristy cer in three years of Wright and his team observed that the r2 Gene pairs up with another set of called which have the ability initiate Tumours within the Tumours remain harmless until the r2 Gene transforms them into malignant cancer cells that spread throughout the that process completed the trans formation that turned r2 into a genetic its surprised this Gene looked like one of the stable Good said Arnold director for the Manitoba Institute of cell biology at the Manitoba cancer research and treatment the implications for human health Are what we thought was a Friend has turned out to be something quite Nasty in some nobody even suspected it might be involved in the progression of can Greenberg in the medical Wrights Dis covery has stunned the normally staid scientific Community and attracted the attention of some of the top researchers in the the research appears today in the prestigious journal of the National Academy of a Washington brain Trust for scientific discoveries change direction some scientists like Greenberg believe the discovery May radically alter the direction science has been travelling in the search for weapons against once you turn Peoples Heads in then they Start moving in that Greenberg what is Clear is it is a really unexpected finding and that is what has triggered the Academy to highlight the Here we Are faced with a Gene nobody Ever considered before in relation to it May be the most important find Marc free press Hui Dhoti fan look ing since the discovery of oncogenes More than a decade the mystery that still remains is finding the key to the transformation of the Jekyll and Hyde Wright said he can Only offer some educated such As a link with environmental environmental agents that we Are exposed to in modern Day life May alter Normal r2 and that could play a role in cancer Wright Ito missing new Gene therapies eventually find a Way to keep the r2 Gene in but Wright said he expects to find no magic Bullet to eradicate partly because different stages of cancer Are governed by different genes and everybody is looking for one drug that can act at a site and kill cancer but what we Are finding out to be More potent is using combinations of Wright continued from a1 their research is to be published today in the proceedings of the Gidus National Academy of sciences in Washington the discovery opens potentially Fertile Avenue for Gene therapy drugs to Stop the r2 Gene from taming Tumour cells into malignant weights team also believes the r2 Gene is a key to halting the growth of some viruses which also grow out of control to overwhelm the body considered a Leader in genetics research in published research in 1095 about another drug that could potentially paralyse the aids me said this latest research is so promising he has joined forces with another Winnipeg Aiping to set up a new Oen sense technologies in elaboration with the University of Manitoba and the Institute of cell the company Hopes to attract Ven Ture capital to develop genetic weapons against cancer and Wright said the r2 Gene appears to act in ways that Are unique from other genes Are Short sequences of the building blocks for life that carry genetic codes from one Genera Tion to the it is not uncommon in cancer to see genes behave that Doest necessarily mean they cause they could be just Wright but this work with this Gene shows there is a cause and effect and it is involved in determining the the Winnipeg team observed the r2 Gene join in a process never described with other genes called oncogenes that can promote the growth of Tumours in Normal often the Tumours Are benign and at they Are rarely but when the r2gene and onco genes pair Tumours spread throughout the body and the results Are continued from a1 the boy and his Brothers and Sisters in the Home were seized by child and family two other siblings were at their grandmothers and remain in her said the Agency is now conducting its own investigation into the eighty Earold and his four guns and ammunition were found by police in the House on Arlington police Are checking weapons serial numbers to see if they were legally none of the weapons were stored under proper storage require said adding the guns and ammo were easily accessible to the Chil Dren in the new Federal gun can tool regulations require guns and ammo be stored separately and locked a simple trigger lock could have prevented the boy from killing Crystal with the two of the four weapons were sawed off shot said and the eight Jearolds Mother and Stepfather May face charges from unsafe storage of firearms to causing death by criminal Shier said the eighty Earold appeared quite familiar with How to Load the pump action shot gun used to kill and it is not a simple gun to contrary to some reports Shier police have no evidence the Stepfather has any gang at John King principal Richard Lei denture clinic 274 Smith Portage Graham Avenue 9437629 9438930 Portoni Llotd by Van to tin Public 198 we accept All a Tui Ini Urano repairs while you wait pm parking at Raar we deliver citywide so m to pm View tags location Mcmil 97 Ranger 4x4 ext cassette 3 Only your Choice Phil Hossack Winnipeg free press Pereira Crystal was liked Graydon said teachers were trying to help grieving students who knew were under a grief management regime right weve deployed All staff to take additional Steps to provide counselling to anyone who needs said asking that reporters leave the school alone for the next few yesterday at Rio amusements on Ellice Crystal Ducharms Favourite several Young friends and one of her cousins said crystals Elma was taking the death of her third oldest of five Chil Dren extremely my auntie is really in said Henry who used to live with Crystal on Agnes said his aunt was still acting As if Crystal was telling people Shes mopping the or just doing it was stupid for this Guy to have so Many guns in the said another also aged shed be alive if they were locked Jose pops who helps run Rio amuse said Crystal often came to play Arcade games and Pool after she was he said in his thick italian she was no she never make trouble with she was very that for and she had a very Nice father and Mth 97 f150 4x4 97 explorer 4x4 2 5 cast locks tilt cruise 2 Only your Choice 399 Mth super 3 loaded 5 onlys Low As Mth 96 Aerostat 4x4 96 Taurus Wagon extended 4 wheel loaded Mth 4 with air locks windows 5 Only As Low As 96 contour go 96 Crown Victoria Power locks 4 wheel Abs 3 Only your Choice 239 4 wheel Power locks 4 Only your Choice 96 win Star go 7 dual air locks 2 your Choice of kids to looking for Good news among the Good news stories youll find in today paper Jaycee Chapman left has been Santa Claus to two generations of and says its been a privilege to Wear the red suit Manitoba Farmers posted the largest income gains in the country during the first nine months of this statistics Canada figures show 95 Lincoln town car series loaded 95 Monte Carlo 2 us loaded 94 Ranger splash loaded 95f150 tilt 95 win Star go 7 with air 95 Taurus 193 Aerostat Sho i Al loaded loaded 94 Ford f150 6 5 94 Taurus go 4 loaded 94 Cavalier 5 air service hours am pm monday through saturday Lincoln Mercury 2420 men quips 3399251 toil free 18003636372 ;