Winnipeg Free Press

Winnipeg Free Press (Newspaper) - May 22, 1997, Winnipeg, Manitoba Winnipeg free May 1997 b3 scientists use viruses to destroy cancer cells associated press Denver two treatments that use cold viruses to invade and destroy cancer cells Are showing Promise in experiments on gravely ill both approaches involve one of the hottest ideas in cancer research finding ways to exploit the genetic flaws that allow cancer cells to Divide and spread cells become cancerous when they develop a series of genetic errors that let them escape the body Standard repair and surveil Lance the most common of these flaws present in about half of All can cers Are in a Gene called this Gene is a kind of genetic watchdog that ordinarily stops cells from reproducing if any of their other genes Are the two experimental approaches were described tuesday at a meet ing of the american society for clinical both use cold viruses to carry in genes that exploit cancers Reliance on a damaged p53 the treatments Are in Early stages of but both have shown at least some effect against Tumours when Given to patients who have failed All Standard in excited by but there is a lot of work left to do before this has any effect on the Way cancer patients Are said Mace Rothenberg of the University of Texas in san the new approaches were devel oped by researchers at Anderson cancer Centre in hous ton and Onyx pharmaceuticals of both involve genetically manipulating the Aden a usually modest microbe that causes colds and intestinal at scientists weakened the adenovirus and gave it a Normal copy of the ps3 then they injected it into the Tumours of 20 patients with advanced lung the intention was to Supply a Good p53 Gene that would take Over for the bad we Hope this will induce the cells to kill said Stephen one of the even in such gravely ill there Are signs this is and the treatment seems to work Best when combined with a Standard chemotherapy the City of Winnipeg notice of Public hearings under the authority of the City of Winnipeg act tha Community committees listed will conduct Public As to receive representations on the applications listed information on applications May be obtained Between and at 395 main Street or at your respective Community committee City Centre Community committee Public hearing unto hi1i7 time locution lion assimhoini1 Avenue l Lozette t City Centre t77jj applicant Maxer file proposal to rezone the land outlined above from an single family a i commercial District for the establishment parking accessory existing real estate for planner at strap Hook to Nassau j City applicant Horvai Jason Homes file proposal to the land above Iron transitional an rm1 family to allow Lor Jie Lons Duclion of in to an existing residential plume planner at 98650 scientists debate his vaccine theres no easy Way to find out what it might do to humans by Daniel Haney associated press locked inside the level 3 Bio Hazard lab at Harvard new England Region Al primate Centre Are a pair of Mon keys codenamed 7188 and they should be dead by in november scientists gave each a big injection of Simian immunodeficiency or the Monkey version of the aids the shot was times More Siv than it usually takes to cause an infect yet nothing what saved the monkeys was an experimental two years ear scientists had Given them a weak or form of the virus was Normal in every Way except that one of its nine genes was clipped losing this called throttles Back the virus ability to make new copies of it caused a Low Grade infection but did not seem to Hurt the monkeys at and some How it primed their immune defences to Ward off real after seeing this Protection in Mon i became an said Ronald a microbiologist at the primate since Siv and his Are so an aids vaccine can be made with exactly the same genes Many believe this should work As Well for humans As it does for but that where agreement Desrosiers and some colleagues would like to begin testing this kind of vaccine in Many others Are adamantly the reason it May Well protect against but no one knows what else it might and theres no easy Way to find just like Ordinary the genetically truncated form used in the vac Cine would cause a lifelong infection in otherwise healthy could the virus somehow regain its lost genes and turn causing the very Dis ease it was meant to Stop could it Trig Ger some other unforeseen disease yet in a nature has already con ducted human at the University of John Sullivan has been following 183 Haemophiliacs who caught his from contaminated clotting proteins in the Early among them Are five who show no signs of could weak viruses explain their Good Fortune Desrosiers Analysed their viruses and found that ones his is indeed missing part of its Nef in this Man had been vac Here was the first tentative evidence that it was in doctors were puzzled by an especially Odd club seven people had caught his from blood donations Given by one infected Man in the Early yet neither the original donor nor any of those who got his blood showed any signs of after hearing of Desrosiers the doctors found they All carried a Strain of his missing part of while these serendipitous discover ies suggest his without a Nef Gene does not trigger intentionally infecting people to prove the Point is another matter but that May be no absolutely Safe alternative is and As David Gold of the american foundation for aids research the need for a vaccine is More Des Perate than alcoholism drug May help smokers associated press san Diego just Days after the government approved one new drug to help smokers kick the a new study shows Early Promise for a drug now used for treating Alco helped people in one study who were try ing to quit smoking by using a nicotine Patch users who took Nal Trevone smoked fewer cigarettes than those taking a Dummy also didst gain a com Mon Sid effect of quitting and they craved Nico Tine the work is very said Stephanie an associate professor of psychiatry at the Yale University medical Only 22 peo ple were in the study and they were followed for Only four its too soon to make any recommendation about using Nal Trevone to help people quit smok said who presented the results tuesday at the american psychiatric associations annual but we think its Worth examining she last the food and drug administration approved another drug the antidepressant Dzyban to help smokers Nal Trevone works it blocks the effects of the brains own feelgood which mimic the effects of morphine or alcohol makes the brain produce More of these so that May be part of the kick peo ple derive from by blocking that Nal Trevone can help people quit drink theres some evidence nicotine also stimulates the brain to produce More of the feelgood sub Omalley so scientists have tried using drugs like in with mixed Omalley study was funded by the National institutes of Bobo takes timeout to Monkey around at Griffith zoo How would you design your own Bank at my i could talk to live person hours a my banker would Reward me for my business with my unlimited Cash rewards could offset of my with Money left i could do of my banking by and still have the option to visit a Bank of Montreal my banker would decisions on the need a managers approval to make one Flat monthly service fee would cover everyday of my if i want satisfied during the first six my banker would refund of my ;